| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50093258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144176 (CHEMBL749557) |
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| Ki | >13000±n/a nM |
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| Citation |  Mullen, G; Napier, J; Balestra, M; DeCory, T; Hale, G; Macor, J; Mack, R; Loch, J; Wu, E; Kover, A; Verhoest, P; Sampognaro, A; Phillips, E; Zhu, Y; Murray, R; Griffith, R; Blosser, J; Gurley, D; Machulskis, A; Zongrone, J; Rosen, A; Gordon, J (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem43:4045-50 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50093258 |
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| n/a |
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| Name | BDBM50093258 |
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| Synonyms: | 3'-Methylspiro[1-azabicyclo[2.2.2]octane-3,4'-2H-tetrahydroimidazolin-2-one] | CHEMBL130124 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H17N3O |
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| Mol. Mass. | 195.2615 |
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| SMILES | CN1C(=O)NCC11CN2CCC1CC2 |TLB:5:6:12.13:10.9,THB:1:6:12.13:10.9,(20.42,-4.1,;20.42,-5.64,;21.67,-6.55,;23.15,-6.07,;21.19,-8.03,;19.64,-8.03,;19.18,-6.55,;18.05,-7.14,;17.48,-5.92,;15.89,-6.44,;16.48,-5.39,;18.17,-4.98,;18.54,-4.03,;17.48,-4.75,)| |
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| Structure | 
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