Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50539698
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1978553 (CHEMBL4611688)
IC50>50000±n/a nM
Citation Davidsson, ÖNilsson, KBrånalt, JAndersson, TBerggren, KChen, YFjellström, OGradén, HGustafsson, LHermansson, NOJansen, FJohannesson, POhlsson, BTyrchan, CWellner, AWellner, EÖlwegård-Halvarsson, M Identification of novel GPR81 agonist lead series for target biology evaluation. Bioorg Med Chem Lett30:0 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50539698
n/a
NameBDBM50539698
Synonyms:CHEMBL4641449
TypeSmall organic molecule
Emp. Form.C20H20ClN3O3S
Mol. Mass.417.909
SMILESCCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)Nc1nc2ccccc2s1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: