Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase SYK |
---|
Ligand | BDBM50546394 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2015641 (CHEMBL4669219) |
---|
IC50 | 0.210000±n/a nM |
---|
Citation | Kawatkar, SP; Barlaam, B; Kemmitt, P; Simpson, I; Watson, D; Wang, P; Lamont, S; Su, Q; Boiko, S; Ikeda, T; Patel, J; Pike, A; Pollard, H; Read, J; Sarkar, U; Wang, H; Wen, Q; Yan, Z; Dowling, JE; Dry, H; Edmondson, SD Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase SYK |
---|
Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
BDBM50546394 |
---|
n/a |
---|
Name | BDBM50546394 |
Synonyms: | CHEMBL4759636 |
Type | Small organic molecule |
Emp. Form. | C21H22N10O |
Mol. Mass. | 430.4658 |
SMILES | CN(C)Cc1cc(nn1C)-c1ccnc(Nc2ccn3cnc(-c4nnc(C)o4)c3c2)n1 |
Structure |
|