Reaction Details |
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Target | Guanylate cyclase soluble subunit alpha-1/beta-1 |
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Ligand | BDBM50547413 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2018158 (CHEMBL4671736) |
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EC50 | 960±n/a nM |
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Citation | Brockunier, L; Stelmach, J; Guo, J; Spencer, T; Rosauer, K; Bansal, A; Cai, SJ; Chen, N; Cummings, J; Huang, L; Johnson, T; Levesque, S; Luo, L; Maloney, K; Metzger, J; Mortko, C; Ortega, K; Pai, LY; Pereira, A; Salituro, G; Shang, J; Shepherd, C; Sherrie Xu, S; Yang, Q; Cui, J; Roy, S; Parmee, E; Raghavan, S Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Guanylate cyclase soluble subunit alpha-1/beta-1 |
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Name: | Guanylate cyclase soluble subunit alpha-1/beta-1 |
Synonyms: | Soluble Guanylate Cyclases | Soluble guanylate cyclase (sGC) | Soluble guanylate cyclase alpha 1 and beta 1 subunits (sGC) | Soluble guanylate cyclase alpha1/beta1 complex | soluble guanylate cyclase activators | soluble guanylate cyclase apha 1 and soluble guanylate cyclase beta 1 |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Guanylate cyclase soluble subunit alpha-1 |
Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
Type: | Enzyme |
Mol. Mass.: | 77457.21 |
Organism: | Homo sapiens (Human) |
Description: | Q02108 |
Residue: | 690 |
Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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Component 2 |
Name: | Guanylate cyclase soluble subunit beta-1 |
Synonyms: | GCYB1_HUMAN | GUC1B3 | GUCSB3 | GUCY1B1 | GUCY1B3 | Guanylate cyclase soluble (GCS-beta-1) | Solube guanylate cyclase beta-1 (sGCβ1) | soluble guanylate cyclase beta-1 (sGC) |
Type: | Enzyme |
Mol. Mass.: | 70496.05 |
Organism: | Homo sapiens (Human) |
Description: | Q02153 |
Residue: | 619 |
Sequence: | MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
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BDBM50547413 |
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n/a |
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Name | BDBM50547413 |
Synonyms: | CHEMBL4787520 |
Type | Small organic molecule |
Emp. Form. | C21H19F2N7O2 |
Mol. Mass. | 439.4181 |
SMILES | COC(=O)N(C)c1c(N)nc(nc1N)-n1nc(Cc2ccccc2F)c2cc(F)ccc12 |
Structure |
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