| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM17752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_141138 (CHEMBL749038) |
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| IC50 | 82±n/a nM |
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| Citation |  Jackson, PF; Tays, KL; Maclin, KM; Ko, YS; Li, W; Vitharana, D; Tsukamoto, T; Stoermer, D; Lu, XC; Wozniak, K; Slusher, BS Design and pharmacological activity of phosphinic acid based NAALADase inhibitors. J Med Chem44:4170-5 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84547.28 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_68365 |
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| Residue: | 752 |
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| Sequence: | MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMK
KAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLS
YPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVN
YARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPG
VKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIG
YDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNV
IGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILF
ASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLT
KELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYT
KNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQ
SYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNP
ILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNK
VDTSKAWREVKRQISIAAFTVQAAAETLREVD
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| BDBM17752 |
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| n/a |
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| Name | BDBM17752 |
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| Synonyms: | 2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]phosphoryl}methyl)pentanedioic acid | CHEMBL64901 | pentanedioic acid analogue, (RS)-2 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12F5O6P |
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| Mol. Mass. | 390.1966 |
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| SMILES | OC(=O)CCC(CP(O)(=O)Cc1c(F)c(F)c(F)c(F)c1F)C(O)=O |
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| Structure | 
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