| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 7 |
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| Ligand | BDBM50548111 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2020016 (CHEMBL4673829) |
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| EC50 | >100000±n/a nM |
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| Citation |  Kettle, JG; Alwan, H; Bista, M; Breed, J; Davies, NL; Eckersley, K; Fillery, S; Foote, KM; Goodwin, L; Jones, DR; Käck, H; Lau, A; Nissink, JW; Read, J; Scott, JS; Taylor, B; Walker, G; Wissler, L; Wylot, M Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. J Med Chem59:2346-61 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 7 |
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| Name: | Toll-like receptor 7 |
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| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
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| Type: | Enzyme |
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| Mol. Mass.: | 120945.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYK1 |
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| Residue: | 1049 |
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| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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| BDBM50548111 |
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| n/a |
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| Name | BDBM50548111 |
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| Synonyms: | CHEMBL4763327 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N5O3 |
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| Mol. Mass. | 329.3538 |
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| SMILES | CNc1nc(OCCOC)nc2n(Cc3ccccc3)c(=O)[nH]c12 |
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| Structure | 
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