| Reaction Details |
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 | Report a problem with these data |
| Target | Oxidized purine nucleoside triphosphate hydrolase |
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| Ligand | BDBM50548108 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2020017 (CHEMBL4673830) |
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| IC50 | 1220±n/a nM |
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| Citation |  Kettle, JG; Alwan, H; Bista, M; Breed, J; Davies, NL; Eckersley, K; Fillery, S; Foote, KM; Goodwin, L; Jones, DR; Käck, H; Lau, A; Nissink, JW; Read, J; Scott, JS; Taylor, B; Walker, G; Wissler, L; Wylot, M Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. J Med Chem59:2346-61 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxidized purine nucleoside triphosphate hydrolase |
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| Name: | Oxidized purine nucleoside triphosphate hydrolase |
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| Synonyms: | 2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197] |
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| Type: | Protein |
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| Mol. Mass.: | 22514.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36639 |
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| Residue: | 156 |
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| Sequence: | MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLT
VDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDD
SYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
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| BDBM50548108 |
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| n/a |
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| Name | BDBM50548108 |
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| Synonyms: | CHEMBL4749745 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19ClFN3O3 |
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| Mol. Mass. | 403.835 |
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| SMILES | COc1cc2ncc(C(=O)N(C)C)c(Nc3ccc(Cl)cc3F)c2cc1OC |
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| Structure | 
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