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TargetOxidized purine nucleoside triphosphate hydrolase
LigandBDBM50189516
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2020017 (CHEMBL4673830)
IC50 2809±n/a nM
Citation Kettle, JG; Alwan, H; Bista, M; Breed, J; Davies, NL; Eckersley, K; Fillery, S; Foote, KM; Goodwin, L; Jones, DR; Käck, H; Lau, A; Nissink, JW; Read, J; Scott, JS; Taylor, B; Walker, G; Wissler, L; Wylot, M Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. J Med Chem59:2346-61 (2016) [PubMed]  Article
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Oxidized purine nucleoside triphosphate hydrolase
Name:Oxidized purine nucleoside triphosphate hydrolase
Synonyms:2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197]
Type:Protein
Mol. Mass.:22514.81
Organism:Homo sapiens (Human)
Description:P36639
Residue:156
Sequence:
MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLT
VDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDD
SYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
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BDBM50189516
n/a
NameBDBM50189516
Synonyms:6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H)-one | 6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol | 9-benzyl-2-(2-methoxyethoxy)-8-oxoadenine | 9-benzyl-2-methoxyethoxy-8-oxoadenine | CHEMBL210884 | SM-360320
TypeSmall organic molecule
Emp. Form.C15H17N5O3
Mol. Mass.315.3272
SMILESCOCCOc1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Structure
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