Reaction Details | |||
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Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM50107899 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_206961 (CHEMBL817272) | ||
IC50 | 38000±n/a nM | ||
Citation | Niimi, T; Orita, M; Okazawa-Igarashi, M; Sakashita, H; Kikuchi, K; Ball, E; Ichikawa, A; Yamagiwa, Y; Sakamoto, S; Tanaka, A; Tsukamoto, S; Fujita, S; Tatsuta, K; Maeda, Y; Chikauchi, K Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening. J Med Chem44:4737-40 (2001) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
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BDBM50107899 | |||
n/a | |||
Name | BDBM50107899 | ||
Synonyms: | 2-[4-(4-{2-[(5-Carboxy-pentyl)-(3-cyclohexyl-propyl)-sulfamoyl]-vinyl}-phenylcarbamoyl)-cyclohexyl]-malonic acid | CHEMBL358512 | ||
Type | Small organic molecule | ||
Emp. Form. | C33H48N2O9S | ||
Mol. Mass. | 648.807 | ||
SMILES | OC(=O)CCCCCN(CCCC1CCCCC1)S(=O)(=O)\C=C\c1ccc(NC(=O)[C@H]2CC[C@@H](CC2)C(C(O)=O)C(O)=O)cc1 |wU:30.30,wD:33.37,(-.42,-5.98,;.35,-4.65,;-.42,-3.32,;1.89,-4.65,;2.66,-5.98,;4.2,-5.98,;4.97,-7.33,;6.51,-7.33,;7.28,-8.66,;6.51,-9.99,;4.97,-9.99,;4.2,-11.33,;2.66,-11.33,;1.87,-12.65,;.33,-12.65,;-.44,-11.33,;.35,-9.99,;1.87,-9.99,;8.82,-8.66,;8.8,-10.2,;8.8,-7.12,;10.36,-8.64,;11.11,-7.29,;12.65,-7.28,;13.39,-5.94,;14.95,-5.91,;15.73,-7.25,;17.27,-7.23,;18.04,-5.88,;17.24,-4.57,;19.58,-5.88,;20.32,-4.53,;21.86,-4.53,;22.65,-5.85,;21.89,-7.2,;20.35,-7.2,;24.19,-5.85,;24.96,-4.5,;26.5,-4.5,;24.17,-3.19,;24.97,-7.17,;26.51,-7.17,;24.2,-8.51,;14.98,-8.58,;13.42,-8.6,)| | ||
Structure |