| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50549701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2025609 (CHEMBL4679422) |
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| IC50 | 37±n/a nM |
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| Citation |  Kimura, H; Suda, H; Kassai, M; Endo, M; Deai, Y; Yahata, M; Miyajima, M; Isobe, Y N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors. Bioorg Med Chem Lett33:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO | KMO_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55831.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487479 |
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| Residue: | 486 |
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| Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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| BDBM50549701 |
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| n/a |
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| Name | BDBM50549701 |
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| Synonyms: | CHEMBL4745247 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O4S2 |
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| Mol. Mass. | 375.422 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)Nc1ncc(s1)-c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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