| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50111291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_222791 |
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| IC50 | 49000±n/a nM |
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| Citation |  Folkes, A; Brown, SD; Canne, LE; Chan, J; Engelhardt, E; Epshteyn, S; Faint, R; Golec, J; Hanel, A; Kearney, P; Leahy, JW; Mac, M; Matthews, D; Prisbylla, MP; Sanderson, J; Simon, RJ; Tesfai, Z; Vicker, N; Wang, S; Webb, RR; Charlton, P Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett12:1063-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50111291 |
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| n/a |
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| Name | BDBM50111291 |
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| Synonyms: | 8-{4-[(4-Hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrole-3-carbonyl)-amino]-phenoxy}-octanoic acid | CHEMBL10116 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N2O6 |
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| Mol. Mass. | 452.4996 |
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| SMILES | OC(=O)CCCCCCCOc1ccc(NC(=O)C2C(=O)NC(C2=O)c2ccccc2)cc1 |
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| Structure | 
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