| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50130293 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2054844 (CHEMBL4709845) |
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| Ki | 49±n/a nM |
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| Citation |  Jin, J; Zhang, K; Dou, F; Hao, C; Zhang, Y; Cao, X; Gao, L; Xiong, J; Liu, X; Liu, BF; Zhang, G; Chen, Y Isoquinolinone derivatives as potent CNS multi-receptor D Eur J Med Chem207:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50130293 |
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| n/a |
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| Name | BDBM50130293 |
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| Synonyms: | 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one | ARIPIPRAZOLE | CHEMBL1112 | US10174011, aripiprazole | US10752588, Compound Aripiprazole | US11498896, Compound Aripiprazole | US9018213, aripprazole | US9156822, Aripiprazole |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27Cl2N3O2 |
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| Mol. Mass. | 448.385 |
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| SMILES | Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl |
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| Structure | 
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