| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
|---|
| Ligand | BDBM50558158 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2062000 (CHEMBL4717253) |
|---|
| IC50 | 4000±n/a nM |
|---|
| Citation |  Ogawa, AK; Bunte, EV; Mal, R; Lan, P; Sun, Z; Crespo, A; Wiltsie, J; Clemas, J; Gibson, J; Contino, L; Lisnock, J; Zhou, G; Garcia-Calvo, M; Jochnowitz, N; Ma, X; Pan, Y; Brown, P; Zamlynny, B; Bateman, T; Leung, D; Xu, L; Tong, X; Liu, K; Crook, M; Sinclair, P Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists. Bioorg Med Chem Lett26:2866-2869 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mineralocorticoid receptor |
|---|
| Name: | Mineralocorticoid receptor |
|---|
| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 107076.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08235 |
|---|
| Residue: | 984 |
|---|
| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
|
|
|
|---|
| BDBM50558158 |
|---|
| n/a |
|---|
| Name | BDBM50558158 |
|---|
| Synonyms: | CHEMBL4746832 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18N2O4S |
|---|
| Mol. Mass. | 358.412 |
|---|
| SMILES | COC(=O)C(c1ccccc1)n1ccc2c(NS(C)(=O)=O)cccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
