Reaction Details |
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Target | Mineralocorticoid receptor |
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Ligand | BDBM50318300 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2062000 (CHEMBL4717253) |
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IC50 | 244±n/a nM |
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Citation | Ogawa, AK; Bunte, EV; Mal, R; Lan, P; Sun, Z; Crespo, A; Wiltsie, J; Clemas, J; Gibson, J; Contino, L; Lisnock, J; Zhou, G; Garcia-Calvo, M; Jochnowitz, N; Ma, X; Pan, Y; Brown, P; Zamlynny, B; Bateman, T; Leung, D; Xu, L; Tong, X; Liu, K; Crook, M; Sinclair, P Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists. Bioorg Med Chem Lett26:2866-2869 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mineralocorticoid receptor |
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Name: | Mineralocorticoid receptor |
Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
Type: | Enzyme |
Mol. Mass.: | 107076.42 |
Organism: | Homo sapiens (Human) |
Description: | P08235 |
Residue: | 984 |
Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
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BDBM50318300 |
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n/a |
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Name | BDBM50318300 |
Synonyms: | CHEMBL1095097 | EPLERENONE | SC-66110 |
Type | Small organic molecule |
Emp. Form. | C24H30O6 |
Mol. Mass. | 414.4914 |
SMILES | COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]23O[C@@H]2C[C@@]2(C)[C@@H](CC[C@@]22CCC(=O)O2)[C@H]13 |r,t:6| |
Structure |
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