Reaction Details |
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Target | Glucocorticoid receptor |
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Ligand | BDBM50510665 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2062015 (CHEMBL4717268) |
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IC50 | >10000±n/a nM |
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Citation | Ogawa, AK; Bunte, EV; Mal, R; Lan, P; Sun, Z; Crespo, A; Wiltsie, J; Clemas, J; Gibson, J; Contino, L; Lisnock, J; Zhou, G; Garcia-Calvo, M; Jochnowitz, N; Ma, X; Pan, Y; Brown, P; Zamlynny, B; Bateman, T; Leung, D; Xu, L; Tong, X; Liu, K; Crook, M; Sinclair, P Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists. Bioorg Med Chem Lett26:2866-2869 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucocorticoid receptor |
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Name: | Glucocorticoid receptor |
Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 |
Type: | Enzyme |
Mol. Mass.: | 85656.87 |
Organism: | Homo sapiens (Human) |
Description: | P04150 |
Residue: | 777 |
Sequence: | MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
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BDBM50510665 |
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n/a |
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Name | BDBM50510665 |
Synonyms: | CHEMBL4439903 |
Type | Small organic molecule |
Emp. Form. | C19H21ClN2O3S |
Mol. Mass. | 392.9 |
SMILES | CC[C@](CO)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc12 |r| |
Structure |
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