Ki Summary

Reaction Details

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Target

Bromodomain-containing protein 4

Ligand

BDBM50566671

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2101510 (CHEMBL4809906)

IC50

15849±n/a nM

Citation

Harrison, LA; Atkinson, SJ; Bassil, A; Chung, CW; Grandi, P; Gray, JRJ; Levernier, E; Lewis, A; Lugo, D; Messenger, C; Michon, AM; Mitchell, DJ; Preston, A; Prinjha, RK; Rioja, I; Seal, JT; Taylor, S; Wall, ID; Watson, RJ; Woolven, JM; Demont, EH Identification of a Series of J Med Chem64:10742-10771 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Bromodomain-containing protein 4

Name:

Bromodomain-containing protein 4

Synonyms:

BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1

Type:

Protein

Mol. Mass.:

152264.84

Organism:

Homo sapiens (Human)

Description:

O60885

Residue:

1362

Sequence:

MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF

BDBM50566671

n/a

Name

BDBM50566671

Synonyms:

CHEMBL4876311

Type

Small organic molecule

Emp. Form.

C19H21N3O3

Mol. Mass.

339.3883

SMILES

CNC(=O)c1cc(cc(Cc2ccccc2)n1)C(=O)N[C@H]1C[C@H](O)C1 |r,wU:22.24,wD:20.21,(10.83,-49.55,;9.49,-48.78,;8.16,-49.55,;6.82,-48.78,;8.16,-51.09,;9.49,-51.87,;9.49,-53.41,;8.16,-54.17,;6.83,-53.41,;5.5,-54.18,;4.16,-53.42,;4.17,-51.88,;2.83,-51.11,;1.5,-51.88,;1.5,-53.43,;2.84,-54.19,;6.83,-51.87,;10.82,-54.18,;10.82,-55.72,;12.15,-53.42,;13.49,-54.19,;13.88,-55.67,;15.37,-55.27,;16.7,-56.04,;14.97,-53.78,)|

Structure