Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Collagenase 3 |
---|
Ligand | BDBM50131521 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_106634 (CHEMBL717018) |
---|
IC50 | 18±n/a nM |
---|
Citation | Levin, JI; Chen, JM; Cheung, K; Cole, D; Crago, C; Santos, ED; Du, X; Khafizova, G; MacEwan, G; Niu, C; Salaski, EJ; Zask, A; Cummons, T; Sung, A; Xu, J; Zhang, Y; Xu, W; Ayral-Kaloustian, S; Jin, G; Cowling, R; Barone, D; Mohler, KM; Black, RA; Skotnicki, JS Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates. Bioorg Med Chem Lett13:2799-803 (2003) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Collagenase 3 |
---|
Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
|
|
|
BDBM50131521 |
---|
n/a |
---|
Name | BDBM50131521 |
Synonyms: | (R)-2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxy-3-methylbutanamide | (R)-2-(4-But-2-ynyloxy-benzenesulfonylamino)-N-hydroxy-3-methyl-butyramide | CHEMBL328751 |
Type | Small organic molecule |
Emp. Form. | C15H20N2O5S |
Mol. Mass. | 340.395 |
SMILES | CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(=O)NO |
Structure |
|