| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase |
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| Ligand | BDBM50571039 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2113647 (CHEMBL4822497) |
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| IC50 | 11±n/a nM |
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| Citation |  Qiu, H; Ali, Z; Bender, A; Caldwell, R; Chen, YY; Fang, Z; Gardberg, A; Glaser, N; Goettsche, A; Goutopoulos, A; Grenningloh, R; Hanschke, B; Head, J; Johnson, T; Jones, C; Jones, R; Kulkarni, S; Maurer, C; Morandi, F; Neagu, C; Poetzsch, S; Potnick, J; Schmidt, R; Roe, K; Viacava Follis, A; Wing, C; Zhu, X; Sherer, B Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors. Bioorg Med Chem40:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase |
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| Name: | Tyrosine-protein kinase |
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| Synonyms: | 2.7.10.2 | Btk | Tyrosine-protein kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76412.09 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_120432 |
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| Residue: | 660 |
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| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPVPRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEE
LRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGS
SHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSELKKVVALYDYMPMNANDLQLRKGE
EYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEG
KEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELI
NYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYG
KWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMAN
GCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSD
FGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKIPYE
RFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADERPSFKILLSNILDVMDEES
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| BDBM50571039 |
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| n/a |
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| Name | BDBM50571039 |
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| Synonyms: | CHEMBL4877846 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38N8O2 |
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| Mol. Mass. | 566.6965 |
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| SMILES | CC(C)n1nc(C)c(c1C)-c1nc2c(ccnc2[nH]1)-c1ccc2[C@@H](CCCCc2c1)NC(=O)c1nc(no1)C(C)(C)C |r| |
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| Structure | 
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