| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50136358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106329 |
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| IC50 | 180±n/a nM |
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| Citation |  Ruel, R; Herpin, TF; Iben, L; Luo, G; Martel, A; Mason, H; Mattson, G; Poirier, B; Ruediger, EH; Shi, D; Thibault, C; Yu, G; Antal Zimanyi, I; Poindexter, GS; Macor, JE beta-alanine dipeptides as MC4R agonists. Bioorg Med Chem Lett13:4341-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50136358 |
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| n/a |
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| Name | BDBM50136358 |
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| Synonyms: | CHEMBL137318 | N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-3-(2,2,2-trifluoro-acetylamino)-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36ClF3N6O3 |
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| Mol. Mass. | 597.072 |
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| SMILES | FC(F)(F)C(=O)NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(CC1)C1CCCCC1 |
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| Structure | 
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