| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor UFO |
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| Ligand | BDBM50571940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116013 (CHEMBL4824954) |
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| IC50 | 29±n/a nM |
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| Citation |  Inoue, S; Yamane, Y; Tsukamoto, S; Murai, N; Azuma, H; Nagao, S; Nishibata, K; Fukushima, S; Ichikawa, K; Nakagawa, T; Hata Sugi, N; Ito, D; Kato, Y; Goto, A; Kakiuchi, D; Ueno, T; Matsui, J; Matsushima, T Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine derivatives as novel selective Axl inhibitors. Bioorg Med Chem Lett48:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor UFO |
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| Name: | Tyrosine-protein kinase receptor UFO |
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| Synonyms: | 2.7.10.1 | Adhesion-related kinase | Ark | Axl | Tyrosine-protein kinase receptor UFO | UFO_MOUSE | Ufo |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98177.22 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120415 |
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| Residue: | 888 |
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| Sequence: | MGRVPLAWWLALCCWGCAAHKDTQTEAGSPFVGNPGNITGARGLTGTLRCELQVQGEPPE
VVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTF
VSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVTGH
SSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHHLHVVSRQPTELEVAWT
PGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYH
IRISCSSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQVLVRWQEPRVPLQGTLLG
YRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVTAYTSAGDGPWSLPVPLEPW
RPGQGQPLHHLVSEPPPRAFSWPWWYVLLGALVAAACVLILALFLVHRRKKETRYGEVFE
PTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGE
FGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQ
GSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTK
RFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVY
TSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCW
ELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQP
DPKDSCSCLTAADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA
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| BDBM50571940 |
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| n/a |
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| Name | BDBM50571940 |
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| Synonyms: | CHEMBL4859147 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H37F2N7O5 |
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| Mol. Mass. | 673.709 |
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| SMILES | CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)CC3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O |
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| Structure | 
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