| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50137503 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143777 |
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| IC50 | 28000±n/a nM |
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| Citation |  Beaulieu, PL; Bös, M; Bousquet, Y; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; LaPlante, S; Poupart, MA; Lefebvre, S; McKercher, G; Pellerin, C; Austel, V; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett14:119-24 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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|
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| BDBM50137503 |
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| n/a |
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| Name | BDBM50137503 |
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| Synonyms: | 1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid methylamide | CHEMBL175173 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O |
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| Mol. Mass. | 334.4149 |
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| SMILES | CNC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccccn1 |
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| Structure | 
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