| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Ligand | BDBM50138552 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_70977 |
|---|
| IC50 | 2400±n/a nM |
|---|
| Citation |  Ho, KK; Appell, KC; Baldwin, JJ; Bohnstedt, AC; Dong, G; Guo, T; Horlick, R; Islam, KR; Kultgen, SG; Masterson, CM; McDonald, E; McMillan, K; Morphy, JR; Rankovic, Z; Sundaram, H; Webb, M 2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors. Bioorg Med Chem Lett14:545-8 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Name: | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 87438.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
|---|
| Residue: | 797 |
|---|
| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
|
|
|
|---|
| BDBM50138552 |
|---|
| n/a |
|---|
| Name | BDBM50138552 |
|---|
| Synonyms: | CHEMBL150409 | N-[4-(4-Hydroxy-phenyl)-butyl]-2-{[2-(4-hydroxy-phenyl)-ethylamino]-methyl}-benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30N2O3 |
|---|
| Mol. Mass. | 418.528 |
|---|
| SMILES | Oc1ccc(CCCCNC(=O)c2ccccc2CNCCc2ccc(O)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
