| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50573262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119346 (CHEMBL4828412) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Hopkins, B; Zhang, H; Bharathan, I; Li, D; Pu, Q; Zhou, H; Martinot, TA; Fradera, X; Lammens, A; Lesburg, CA; Cohen, RD; Ballard, J; Knemeyer, I; Otte, K; Vincent, S; Miller, JR; Solban, N; Cheng, M; Geda, P; Smotrov, N; Song, X; Bennett, DJ; Han, Y Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors. ACS Med Chem Lett12:1435-1440 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50573262 |
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| n/a |
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| Name | BDBM50573262 |
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| Synonyms: | CHEMBL4870929 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22FN5O |
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| Mol. Mass. | 415.4628 |
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| SMILES | [H][C@@]12C[C@]1([H])c1nc(ccc1N(C2)c1ccnc(C)n1)C1(CC1)NC(=O)c1ccc(F)cc1 |r| |
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| Structure | 
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