| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50573269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119386 (CHEMBL4828452) |
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| IC50 | 0.890000±n/a nM |
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| Citation |  Wang, B; Feng, W; Wang, J; Dong, Y; Liu, Y; Yao, Y; Zhang, J; Shi, W; Liu, L; Zhang, H; He, X; Chang, X; Wang, X; Xu, H; Liu, F; Feng, J Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton. Bioorg Med Chem47:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50573269 |
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| n/a |
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| Name | BDBM50573269 |
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| Synonyms: | CHEMBL4860213 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H51F3N8O6S |
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| Mol. Mass. | 888.997 |
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| SMILES | CN(C)CCCNc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(cc2)C(F)(F)F)CC1 |t:47| |
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| Structure | 
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