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TargetApoptosis regulator Bcl-2
LigandBDBM50573282
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2119386 (CHEMBL4828452)
IC50 0.500000±n/a nM
Citation Wang, BFeng, WWang, JDong, YLiu, YYao, YZhang, JShi, WLiu, LZhang, HHe, XChang, XWang, XXu, HLiu, FFeng, J Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton. Bioorg Med Chem47:0 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM50573282
n/a
NameBDBM50573282
Synonyms:CHEMBL4851332
TypeSmall organic molecule
Emp. Form.C48H54F3N7O7S
Mol. Mass.930.045
SMILESCCN1CCC(COc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)CC1 |t:48|
Structure
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