Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM50573271 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2119387 (CHEMBL4828453) |
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IC50 | 36±n/a nM |
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Citation | Wang, B; Feng, W; Wang, J; Dong, Y; Liu, Y; Yao, Y; Zhang, J; Shi, W; Liu, L; Zhang, H; He, X; Chang, X; Wang, X; Xu, H; Liu, F; Feng, J Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton. Bioorg Med Chem47:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM50573271 |
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n/a |
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Name | BDBM50573271 |
Synonyms: | CHEMBL4858569 |
Type | Small organic molecule |
Emp. Form. | C46H51F3N8O6S |
Mol. Mass. | 901.007 |
SMILES | CN1CCC(CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(cc3)C(F)(F)F)CC2)C1 |t:47| |
Structure |
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