| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
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| Ligand | BDBM50576845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2127828 (CHEMBL4837173) |
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| EC50 | 3810±n/a nM |
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| Citation |  Yamada, Y; Gilliland, K; Xiang, Z; Haymer, D; Crocker, KE; Loch, MT; Schulte, ML; Rodriguez, AL; Niswender, CM; Jeffrey Conn, P; Lindsley, CW; Melancon, BJ Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 2 |
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| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GRM2_RAT | Gprc1b | Grm2 | Mglur2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95786.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105034 |
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| Residue: | 872 |
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| Sequence: | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGAL
ESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAP
RASANLGQGSGSQFVPTVCNGREVVDSTTSSL
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| BDBM50576845 |
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| n/a |
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| Name | BDBM50576845 |
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| Synonyms: | CHEMBL4853089 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34FNO5 |
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| Mol. Mass. | 459.5503 |
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| SMILES | CN(C)C(=O)c1cc(OCCCCOc2ccc(C(=O)CC(C)(C)C)c(O)c2C)ccc1F |
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| Structure | 
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