| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
|---|
| Ligand | BDBM50576821 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2127828 (CHEMBL4837173) |
|---|
| EC50 | 142±n/a nM |
|---|
| Citation |  Yamada, Y; Gilliland, K; Xiang, Z; Haymer, D; Crocker, KE; Loch, MT; Schulte, ML; Rodriguez, AL; Niswender, CM; Jeffrey Conn, P; Lindsley, CW; Melancon, BJ Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 2 |
|---|
| Name: | Metabotropic glutamate receptor 2 |
|---|
| Synonyms: | GRM2_RAT | Gprc1b | Grm2 | Mglur2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 95786.41 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_105034 |
|---|
| Residue: | 872 |
|---|
| Sequence: | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGAL
ESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAP
RASANLGQGSGSQFVPTVCNGREVVDSTTSSL
|
|
|
|---|
| BDBM50576821 |
|---|
| n/a |
|---|
| Name | BDBM50576821 |
|---|
| Synonyms: | CHEMBL4862801 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27FO6 |
|---|
| Mol. Mass. | 418.4553 |
|---|
| SMILES | C[C@@H](COc1ccc(C(=O)CC(C)(C)C)c(O)c1C)Oc1ccc(F)c(c1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
