| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TNNI3K |
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| Ligand | BDBM50578189 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2132285 (CHEMBL4841800) |
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| IC50 | 23±n/a nM |
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| Citation |  Patterson, JR; Graves, AP; Stoy, P; Cheung, M; Desai, TA; Fries, H; Gatto, GJ; Holt, DA; Shewchuk, L; Totoritis, R; Wang, L; Kallander, LS Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38?, and B-Raf. J Med Chem64:15651-15670 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase TNNI3K |
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| Name: | Serine/threonine-protein kinase TNNI3K |
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| Synonyms: | CARK | Serine/threonine-protein kinase TNNI3K | TNI3K_HUMAN | TNNI3K |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 92855.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_7705748 |
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| Residue: | 835 |
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| Sequence: | MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE
QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH
FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK
ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL
DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG
GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG
RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ
YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG
HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT
GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE
ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA
LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
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| BDBM50578189 |
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| n/a |
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| Name | BDBM50578189 |
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| Synonyms: | CHEMBL4856992 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19F3N4O4 |
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| Mol. Mass. | 484.4273 |
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| SMILES | COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c2cc1OC |
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| Structure | 
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