Reaction Details |
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Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Ligand | BDBM50151530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306551 (CHEMBL828296) |
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IC50 | 140±n/a nM |
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Citation | Vergne, F; Bernardelli, P; Lorthiois, E; Pham, N; Proust, E; Oliveira, C; Mafroud, AK; Royer, F; Wrigglesworth, R; Schellhaas, J; Barvian, M; Moreau, F; Idrissi, M; Tertre, A; Bertin, B; Coupe, M; Berna, P; Soulard, P Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorg Med Chem Lett14:4607-13 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
Type: | Enzyme |
Mol. Mass.: | 55514.96 |
Organism: | Homo sapiens (Human) |
Description: | Q13946 |
Residue: | 482 |
Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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BDBM50151530 |
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n/a |
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Name | BDBM50151530 |
Synonyms: | 3-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-benzoic acid | CHEMBL185604 |
Type | Small organic molecule |
Emp. Form. | C16H12ClN3O2S |
Mol. Mass. | 345.803 |
SMILES | Cn1nc(s\c1=N/c1cccc(c1)C(O)=O)-c1ccc(Cl)cc1 |
Structure |
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