| Reaction Details |
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 | Report a problem with these data |
| Target | 2-5A-dependent ribonuclease |
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| Ligand | BDBM50241367 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2158720 (CHEMBL5043470) |
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| IC50 | 1630±n/a nM |
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| Citation |  Tang, J; Dong, B; Liu, M; Liu, S; Niu, X; Gaughan, C; Asthana, A; Zhou, H; Xu, Z; Zhang, G; Silverman, RH; Huang, H Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery. J Med Chem65:1445-1457 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-5A-dependent ribonuclease |
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| Name: | 2-5A-dependent ribonuclease |
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| Synonyms: | 2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_HUMAN | RNASEL | RNS4 | RNase L | Ribonuclease 4 | Ribonuclease L |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83534.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_164152 |
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| Residue: | 741 |
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| Sequence: | MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW
TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE
CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH
VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK
TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD
CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK
LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF
YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG
YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE
DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG
NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG
DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH
SPNKPQCDGAGGASGLASPGC
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| BDBM50241367 |
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| n/a |
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| Name | BDBM50241367 |
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| Synonyms: | 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one | CHEMBL251254 | quercetin 3-O-beta-D-glucopyranoside |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20O12 |
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| Mol. Mass. | 464.3763 |
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| SMILES | OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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