| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
|---|
| Ligand | BDBM50585602 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2163502 (CHEMBL5048363) |
|---|
| IC50 | 31±n/a nM |
|---|
| Citation |  Lee, HF; Lacbay, CM; Boutin, R; Matralis, AN; Park, J; Waller, DD; Guan, TL; Sebag, M; Tsantrizos, YS Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem65:2471-2496 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Geranylgeranyl pyrophosphate synthase |
|---|
| Name: | Geranylgeranyl pyrophosphate synthase |
|---|
| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
|---|
| Type: | Homooctamer; transferase |
|---|
| Mol. Mass.: | 34867.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
|---|
| Residue: | 300 |
|---|
| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
|
|
|
|---|
| BDBM50585602 |
|---|
| n/a |
|---|
| Name | BDBM50585602 |
|---|
| Synonyms: | CHEMBL5075029 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19FN4O7P2S |
|---|
| Mol. Mass. | 552.409 |
|---|
| SMILES | Cc1ccc(NC(=O)c2cccc(c2)-c2nc(NC(P(O)(O)=O)P(O)(O)=O)c3ccsc3n2)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
