Reaction Details | |||
---|---|---|---|
![]() | Report a problem with these data | ||
Target | Isocitrate dehydrogenase [NADP] cytoplasmic | ||
Ligand | BDBM416173 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2165763 (CHEMBL5050624) | ||
IC50 | 43±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Isocitrate dehydrogenase [NADP] cytoplasmic | |||
Name: | Isocitrate dehydrogenase [NADP] cytoplasmic | ||
Synonyms: | Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD | ||
Type: | Protein | ||
Mol. Mass.: | 46661.29 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75874 | ||
Residue: | 414 | ||
Sequence: |
| ||
BDBM416173 | |||
n/a | |||
Name | BDBM416173 | ||
Synonyms: | 6-{[trans-4-(1- methylethoxy)cyclohexyl]car- bonyl}-8-(6-oxa-2- azaspiro[3.5]non-2-yl)-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine | US10442819, Example 318 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H38N4O3 | ||
Mol. Mass. | 490.637 | ||
SMILES | CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CC2(C1)CCCOC2 |r,wU:7.10,wD:4.3,(7.13,5.88,;6.36,4.54,;7.13,3.21,;4.82,4.54,;4.05,3.21,;2.51,3.21,;1.74,1.88,;2.51,.54,;4.05,.54,;4.82,1.88,;1.74,-.79,;.2,-.79,;2.51,-2.12,;4.05,-2.12,;5.01,-3.33,;6.48,-2.87,;7.61,-3.92,;7.27,-5.42,;5.8,-5.88,;4.67,-4.83,;3.28,-5.5,;1.9,-4.83,;.77,-5.88,;-.7,-5.42,;-1.05,-3.92,;.08,-2.87,;1.55,-3.33,;-2.54,-3.52,;-3.31,-2.19,;-4.64,-2.96,;-3.87,-4.29,;-5.73,-4.05,;-7.22,-3.65,;-7.61,-2.16,;-6.52,-1.07,;-5.04,-1.47,)| | ||
Structure | ![]() |