| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM50589562 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2193766 (CHEMBL5106126) |
|---|
| IC50 | 1150±n/a nM |
|---|
| Citation |  Paolino, M; Rullo, M; Maramai, S; de Candia, M; Pisani, L; Catto, M; Mugnaini, C; Brizzi, A; Cappelli, A; Olivucci, M; Corelli, F; Altomare, CD Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors. RSC Med Chem13:873-883 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67792.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22303 |
|---|
| Residue: | 614 |
|---|
| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
|
|
|
|---|
| BDBM50589562 |
|---|
| n/a |
|---|
| Name | BDBM50589562 |
|---|
| Synonyms: | CHEMBL5209347 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25NO2 |
|---|
| Mol. Mass. | 335.4394 |
|---|
| SMILES | CCN(CC)Cc1ccc(\C=C2\Cc3cc(OC)ccc3C2=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
