| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha |
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| Ligand | BDBM50599596 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2231145 (CHEMBL5144917) |
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| IC50 | 11±n/a nM |
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| Citation |  Andrews, DM; Cartic, S; Cosulich, S; Divecha, N; Faulder, P; Flemington, V; Kern, O; Kettle, JG; MacDonald, E; McKelvie, J; Pike, KG; Roberts, B; Rowlinson, R; Smith, JM; Stockley, M; Swarbrick, ME; Treinies, I; Waring, MJ Identification and optimization of a novel series of selective PIP5K inhibitors. Bioorg Med Chem54:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha |
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| Name: | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha |
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| Synonyms: | PI51A_HUMAN | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62644.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774304 |
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| Residue: | 562 |
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| Sequence: | MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP
IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK
ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
LQMLTTSTTLEKLEVAESEFTH
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| BDBM50599596 |
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| n/a |
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| Name | BDBM50599596 |
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| Synonyms: | CHEMBL5191668 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26N4O3 |
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| Mol. Mass. | 430.4989 |
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| SMILES | CC(=O)Nc1cc(Nc2ccccc2)cc(c1)-c1ccnc(NC(=O)C2CCOCC2)c1 |
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| Structure | 
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