| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma |
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| Ligand | BDBM50599594 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2231147 (CHEMBL5144919) |
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| IC50 | 9.5±n/a nM |
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| Citation |  Andrews, DM; Cartic, S; Cosulich, S; Divecha, N; Faulder, P; Flemington, V; Kern, O; Kettle, JG; MacDonald, E; McKelvie, J; Pike, KG; Roberts, B; Rowlinson, R; Smith, JM; Stockley, M; Swarbrick, ME; Treinies, I; Waring, MJ Identification and optimization of a novel series of selective PIP5K inhibitors. Bioorg Med Chem54:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma |
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| Name: | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma |
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| Synonyms: | KIAA0589 | PI51C_HUMAN | PIP5K1-gamma | PIP5K1C | PIP5KIgamma | Phosphatidylinositol 4-phosphate 5-kinase type I gamma | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | PtdIns(4)P-5-kinase 1 gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73241.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508846 |
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| Residue: | 668 |
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| Sequence: | MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGH
RGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGS
NLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVT
SDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNN
ILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVK
TLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMES
IQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDG
DTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQI
PSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSP
SETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEAS
PAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPP
ASDGESDT
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| BDBM50599594 |
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| n/a |
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| Name | BDBM50599594 |
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| Synonyms: | CHEMBL5171272 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26N4O3 |
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| Mol. Mass. | 430.4989 |
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| SMILES | CNC(=O)c1cc(Nc2ccccc2)cc(c1)-c1ccnc(NC(=O)C2CCOCC2)c1 |
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| Structure | 
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