| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50602199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2239669 (CHEMBL5153565) |
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| IC50 | 63±n/a nM |
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| Citation |  Sun, P; Wang, J; Khan, KS; Yang, W; Ng, BW; Ilment, N; Zessin, M; Bülbül, EF; Robaa, D; Erdmann, F; Schmidt, M; Romier, C; Schutkowski, M; Cheng, AS; Sippl, W Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties. J Med Chem65:16313-16337 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50602199 |
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| n/a |
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| Name | BDBM50602199 |
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| Synonyms: | CHEMBL5199264 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O |
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| Mol. Mass. | 377.4827 |
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| SMILES | CCCCCCNNC(=O)c1cnc(NCc2cccc3ccccc23)nc1 |
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| Structure | 
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