| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50603357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2243774 (CHEMBL5157984) |
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| EC50 | 131±n/a nM |
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| Citation |  Park, SJ; Yeon, SK; Kim, Y; Kim, HJ; Kim, S; Kim, J; Choi, JW; Kim, B; Lee, EH; Kim, R; Seo, SH; Lee, J; Kim, JW; Lee, HY; Hwang, H; Bahn, YS; Cheong, E; Park, JH; Park, KD Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis. J Med Chem65:3539-3562 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50603357 |
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| n/a |
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| Name | BDBM50603357 |
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| Synonyms: | CHEMBL5183758 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N4O2 |
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| Mol. Mass. | 404.5047 |
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| SMILES | COC(=O)C1CN(Cc2ccc(cc2)-c2cn(nn2)-c2ccc(cc2)C(C)(C)C)C1 |
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| Structure | 
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