| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 5 |
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| Ligand | BDBM50603801 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2245287 (CHEMBL5159497) |
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| IC50 | 4.4±n/a nM |
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| Citation |  Tomassi, S; Dimmito, MP; Cai, M; D'Aniello, A; Del Bene, A; Messere, A; Liu, Z; Zhu, T; Hruby, VJ; Stefanucci, A; Cosconati, S; Mollica, A; Di Maro, S CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. J Med Chem65:4007-4017 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 5 |
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| Name: | Melanocortin receptor 5 |
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| Synonyms: | MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36612.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33032 |
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| Residue: | 325 |
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| Sequence: | MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
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| BDBM50603801 |
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| n/a |
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| Name | BDBM50603801 |
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| Synonyms: | CHEMBL5203580 |
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| Type | Small organic molecule |
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| Emp. Form. | C54H70N14O8S2 |
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| Mol. Mass. | 1107.353 |
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| SMILES | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(CSC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]cn3)NC1=O)C(N)=O)c2 |r| |
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| Structure | 
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