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TargetBcl-2-like protein 2
LigandBDBM50162774
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2249564 (CHEMBL5163774)
Ki 245±n/a nM
Citation Feng, XYan, ZZhou, FLou, JLyu, XRen, XZeng, ZLiu, CZhang, SZhu, DHuang, HYang, JZhao, Y Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells. Eur J Med Chem236:0 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 2
Name:Bcl-2-like protein 2
Synonyms:Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:Protein
Mol. Mass.:20742.61
Organism:Homo sapiens (Human)
Description:n/a
Residue:193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG
QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL
GALVTVGAFFASK
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  Blast E-value cutoff:
BDBM50162774
n/a
NameBDBM50162774
Synonyms:ABT-199 | US11420968, Example ABT-199 | Venetoclax
TypeSmall organic molecule
Emp. Form.C45H50ClN7O7S
Mol. Mass.868.439
SMILESCC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57|
Structure
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