| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50162774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2249565 (CHEMBL5163775) |
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| Ki | 48±n/a nM |
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| Citation |  Feng, X; Yan, Z; Zhou, F; Lou, J; Lyu, X; Ren, X; Zeng, Z; Liu, C; Zhang, S; Zhu, D; Huang, H; Yang, J; Zhao, Y Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells. Eur J Med Chem236:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50162774 |
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| n/a |
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| Name | BDBM50162774 |
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| Synonyms: | ABT-199 | US11420968, Example ABT-199 | Venetoclax |
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| Type | Small organic molecule |
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| Emp. Form. | C45H50ClN7O7S |
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| Mol. Mass. | 868.439 |
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| SMILES | CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| |
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| Structure | 
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