Reaction Details |
| Report a problem with these data |
Target | RAC-gamma serine/threonine-protein kinase |
---|
Ligand | BDBM50606334 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2254477 (CHEMBL5168687) |
---|
IC50 | 6.6±n/a nM |
---|
Citation | Ma, C; Wu, J; Wang, L; Ji, X; Wu, Y; Miao, L; Chen, D; Zhang, L; Wu, Y; Feng, H; Tang, Y; Zhou, Q; Pei, J; Yang, X; Xu, D; You, Q; Xie, Y Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J Med Chem65:8144-8168 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAC-gamma serine/threonine-protein kinase |
---|
Name: | RAC-gamma serine/threonine-protein kinase |
Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
Type: | Enzyme |
Mol. Mass.: | 55769.36 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 479 |
Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
|
|
|
BDBM50606334 |
---|
n/a |
---|
Name | BDBM50606334 |
Synonyms: | CHEMBL5172419 |
Type | Small organic molecule |
Emp. Form. | C26H33ClN6O2 |
Mol. Mass. | 497.032 |
SMILES | [H][C@@]12CN(C[C@]1([H])CN(C2)c1ncnc2NC(=O)C[C@@H](C)c12)C(=O)[C@H](CNC(C)C)c1ccc(Cl)cc1 |r| |
Structure |
|