| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein phosphatase alpha |
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| Ligand | BDBM50188776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_389279 (CHEMBL868035) |
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| IC50 | 900±n/a nM |
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| Citation |  Amarasinghe, KK; Evdokimov, AG; Evidokimov, AG; Xu, K; Clark, CM; Maier, MB; Srivastava, A; Colson, AO; Gerwe, GS; Stake, GE; Howard, BW; Pokross, ME; Gray, JL; Peters, KG Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg Med Chem Lett16:4252-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein phosphatase alpha |
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| Name: | Receptor-type tyrosine-protein phosphatase alpha |
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| Synonyms: | PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 90719.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18433 |
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| Residue: | 802 |
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| Sequence: | MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
YEFCYKVVQEYIDAFSDYANFK
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| BDBM50188776 |
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| n/a |
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| Name | BDBM50188776 |
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| Synonyms: | 4-(2-benzyl-3-methoxy-2-(methoxycarbonyl)-3-oxopropyl)phenylsulfamic acid | CHEMBL379000 | {4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO7S |
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| Mol. Mass. | 407.438 |
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| SMILES | COC(=O)C(Cc1ccccc1)(Cc1ccc(NS(O)(=O)=O)cc1)C(=O)OC |
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| Structure | 
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