Reaction Details |
| Report a problem with these data |
Target | Tryptophan 2,3-dioxygenase |
---|
Ligand | BDBM50606621 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2260711 (CHEMBL5215722) |
---|
IC50 | 410±n/a nM |
---|
Citation | Ning, XL; Li, YZ; Huo, C; Deng, J; Gao, C; Zhu, KR; Wang, M; Wu, YX; Yu, JL; Ren, YL; Luo, ZY; Li, G; Chen, Y; Wang, SY; Peng, C; Yang, LL; Wang, ZY; Wu, Y; Qian, S; Li, GB X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J Med Chem64:8303-8332 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tryptophan 2,3-dioxygenase |
---|
Name: | Tryptophan 2,3-dioxygenase |
Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
Type: | PROTEIN |
Mol. Mass.: | 47874.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_825691 |
Residue: | 406 |
Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
|
|
|
BDBM50606621 |
---|
n/a |
---|
Name | BDBM50606621 |
Synonyms: | CHEMBL5220129 |
Type | Small organic molecule |
Emp. Form. | C15H21N3O |
Mol. Mass. | 259.3467 |
SMILES | Cc1cc(NC[C@@H]2CCCC[C@H]2O)c2cn[nH]c2c1 |r| |
Structure |
|