| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostacyclin receptor |
|---|
| Ligand | BDBM50191138 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_400373 (CHEMBL912671) |
|---|
| IC50 | 115±n/a nM |
|---|
| Citation |  Tanaka, A; Hattori, K; Taniguchi, K; Okitsu, O; Tabuchi, S; Nishio, M; Nagakura, Y; Maeda, N; Murai, H; Seki, J Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6. Bioorg Med Chem Lett16:4861-4 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostacyclin receptor |
|---|
| Name: | Prostacyclin receptor |
|---|
| Synonyms: | PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 40968.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The membranes prepared from human platelet were used in binding assay. |
|---|
| Residue: | 386 |
|---|
| Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
|
|
|
|---|
| BDBM50191138 |
|---|
| n/a |
|---|
| Name | BDBM50191138 |
|---|
| Synonyms: | CHEMBL405770 | sodium 2-(3-(((1S,2S)-2-(4,5-diphenyloxazol-2-yl)cyclohexyl)methyl)phenoxy)acetate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H28NO4 |
|---|
| Mol. Mass. | 466.5482 |
|---|
| SMILES | [O-]C(=O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
