Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Poly [ADP-ribose] polymerase tankyrase-2 |
---|
Ligand | BDBM50409635 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2268409 |
---|
IC50 | 36±n/a nM |
---|
Citation | Buchstaller, HP; Anlauf, U; Dorsch, D; Kögler, S; Kuhn, D; Lehmann, M; Leuthner, B; Lodholz, S; Musil, D; Radtki, D; Rettig, C; Ritzert, C; Rohdich, F; Schneider, R; Wegener, A; Weigt, S; Wilkinson, K; Esdar, C Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem64:10371-10392 (2021) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Poly [ADP-ribose] polymerase tankyrase-2 |
---|
Name: | Poly [ADP-ribose] polymerase tankyrase-2 |
Synonyms: | (ARTD6 or PARP5b) | PARP5B | Poly [ADP-ribose] polymerase tankyrase-2 | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | TPoly [ADP-ribose] polymerase tankyrase-2 | Tankyrase 2 | Tankyrase II | Tankyrase-2 | Tankyrase-2 (TNKS-2) | Tankyrase-2 (TNKS2) |
Type: | Enzyme |
Mol. Mass.: | 126937.16 |
Organism: | Homo sapiens (Human) |
Description: | Q9H2K2 |
Residue: | 1166 |
Sequence: | MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR
DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK
DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV
KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL
LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQIMRPEGMVDG
|
|
|
BDBM50409635 |
---|
n/a |
---|
Name | BDBM50409635 |
Synonyms: | CHEMBL5284505 |
Type | Small organic molecule |
Emp. Form. | C16H17N3O2 |
Mol. Mass. | 283.3251 |
SMILES | Cc1cc2n(cc([nH]c2=O)-c2ccc(cc2)C(C)(C)O)n1 |
Structure |
|