Reaction Details |
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Target | Melanin-concentrating hormone receptor 1 |
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Ligand | BDBM50197136 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_408729 (CHEMBL908289) |
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IC50 | 13±n/a nM |
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Citation | Lynch, JK; Freeman, JC; Judd, AS; Iyengar, R; Mulhern, M; Zhao, G; Napier, JJ; Wodka, D; Brodjian, S; Dayton, BD; Falls, D; Ogiela, C; Reilly, RM; Campbell, TJ; Polakowski, JS; Hernandez, L; Marsh, KC; Shapiro, R; Knourek-Segel, V; Droz, B; Bush, E; Brune, M; Preusser, LC; Fryer, RM; Reinhart, GA; Houseman, K; Diaz, G; Mikhail, A; Limberis, JT; Sham, HL; Collins, CA; Kym, PR Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem49:6569-84 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanin-concentrating hormone receptor 1 |
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Name: | Melanin-concentrating hormone receptor 1 |
Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 45976.27 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
Residue: | 422 |
Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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BDBM50197136 |
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n/a |
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Name | BDBM50197136 |
Synonyms: | CHEMBL387178 | N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-6,7-difluoro-4-oxo-4H-chromene-2-carboxamide |
Type | Small organic molecule |
Emp. Form. | C23H20F2N2O5 |
Mol. Mass. | 442.4121 |
SMILES | Fc1cc2oc(cc(=O)c2cc1F)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1 |
Structure |
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