| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Ligand | BDBM50611043 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2282736 |
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| IC50 | 220±n/a nM |
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| Citation |  Wortmann, L; Bräuer, N; Holton, SJ; Irlbacher, H; Weiske, J; Lechner, C; Meier, R; Karén, J; Siöberg, CB; Pütter, V; Christ, CD; Ter Laak, A; Lienau, P; Lesche, R; Nicke, B; Cheung, SH; Bauser, M; Haegebarth, A; von Nussbaum, F; Mumberg, D; Lemos, C Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J Med Chem64:15883-15911 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Synonyms: | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46228.59 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104274 |
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| Residue: | 406 |
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| Sequence: | MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVM
LMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSA
PLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLG
MYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFIN
EGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEE
EGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDI
LTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
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| BDBM50611043 |
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| n/a |
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| Name | BDBM50611043 |
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| Synonyms: | CHEMBL5272762 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22FN5O2 |
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| Mol. Mass. | 455.4836 |
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| SMILES | CC[C@@H](Nc1c(C#N)c(nc2cnccc12)-c1ccc(cc1)-c1ccc(F)cc1OC)C(N)=O |r| |
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| Structure | 
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