Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Androgen receptor | ||
Ligand | BDBM50205097 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_438312 (CHEMBL887414) | ||
EC50 | 79±n/a nM | ||
Citation | Hamann, LG; Manfredi, MC; Sun, C; Krystek, SR; Huang, Y; Bi, Y; Augeri, DJ; Wang, T; Zou, Y; Betebenner, DA; Fura, A; Seethala, R; Golla, R; Kuhns, JE; Lupisella, JA; Darienzo, CJ; Custer, LL; Price, JL; Johnson, JM; Biller, SA; Zahler, R; Ostrowski, J Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators. Bioorg Med Chem Lett17:1860-4 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Androgen receptor | |||
Name: | Androgen receptor | ||
Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
Type: | Receptor | ||
Mol. Mass.: | 99185.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | CHO cells were stably transfected with human AR gene. | ||
Residue: | 920 | ||
Sequence: |
| ||
BDBM50205097 | |||
n/a | |||
Name | BDBM50205097 | ||
Synonyms: | 3-ethyl-4-((7R,7aS)-7-hydroxy-1,3-dioxo-tetrahydro-1H-pyrrolo[1,2-e]imidazol-2(3H)-yl)benzonitrile | CHEMBL231328 | ||
Type | Small organic molecule | ||
Emp. Form. | C15H15N3O3 | ||
Mol. Mass. | 285.2979 | ||
SMILES | CCc1cc(ccc1-n1c(O)c2[C@H](O)CCn2c1=O)C#N |wU:12.13,(4.34,-4.72,;3.58,-3.37,;4.36,-2.05,;5.9,-2.06,;6.68,-.73,;5.91,.61,;4.37,.62,;3.6,-.71,;2.06,-.7,;1.16,.55,;1.65,2.01,;-.3,.08,;-1.76,.57,;-2.23,2.04,;-2.68,-.68,;-1.77,-1.93,;-.31,-1.46,;1.15,-1.94,;1.62,-3.41,;8.22,-.73,;9.76,-.74,)| | ||
Structure |