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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Androgen receptor | ||
| Ligand | BDBM50205117 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_438312 (CHEMBL887414) | ||
| EC50 | >10000±n/a nM | ||
| Citation |  Hamann, LG; Manfredi, MC; Sun, C; Krystek, SR; Huang, Y; Bi, Y; Augeri, DJ; Wang, T; Zou, Y; Betebenner, DA; Fura, A; Seethala, R; Golla, R; Kuhns, JE; Lupisella, JA; Darienzo, CJ; Custer, LL; Price, JL; Johnson, JM; Biller, SA; Zahler, R; Ostrowski, J Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators. Bioorg Med Chem Lett17:1860-4 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Androgen receptor | |||
| Name: | Androgen receptor | ||
| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
| Type: | Receptor | ||
| Mol. Mass.: | 99185.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | CHO cells were stably transfected with human AR gene. | ||
| Residue: | 920 | ||
| Sequence: |
| ||
| BDBM50205117 | |||
| n/a | |||
| Name | BDBM50205117 | ||
| Synonyms: | 2-hydroxy-4-((7R,7aS)-7-hydroxy-1,3-dioxo-tetrahydro-1H-pyrrolo[1,2-e]imidazol-2(3H)-yl)-3-methylbenzonitrile | CHEMBL389805 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C14H13N3O4 | ||
| Mol. Mass. | 287.2707 | ||
| SMILES | Cc1c(O)c(ccc1-n1c(O)c2[C@H](O)CCn2c1=O)C#N |wU:12.13,(19.73,-50.01,;20.51,-48.68,;22.05,-48.7,;22.81,-50.04,;22.83,-47.37,;22.06,-46.02,;20.52,-46.02,;19.75,-47.34,;18.21,-47.34,;17.31,-46.09,;17.8,-44.63,;15.85,-46.55,;14.38,-46.07,;13.92,-44.6,;13.47,-47.31,;14.37,-48.56,;15.84,-48.09,;17.3,-48.58,;17.76,-50.05,;24.37,-47.37,;25.91,-47.37,)| | ||
| Structure | 
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